A network approach reveals driver genes associated with survival of patients with triple-negative breast cancer April 19, 2021; IF=5.4 https://doi.org/10.1016/j.isci.2021.102451 1、WGCNA分析 （1）对773个来自TCGA的BRCA(包括92个TNBC)的31338个基因表达...
Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Sinisan Against Non-Alcoholic Fatty Liver Disease（四逆散–非酒精性脂肪肝） 27 August 2021 Front Pharmacol, IF=5.8 DOI: 10.3389/fphar.2021.693701 分析思路 文章的流程图 1、数据收集 1.1 TCM数据...
Network-based prediction of drug combinations Nature communication 2019 / 03 IF=15 https://doi.org/10.1038/s41467-019-09186-x 文章使用数据 1、PPI high-quality protein-protein interactions (PPIs) 原文说有243,603 PPIs connecting 16,677 unique proteins ，但是根据文章附件链接只有217160 PPIs, 涉及15970...
本次的两篇文章属于同一团队，第一篇文章侧重提出计算方法；第二篇文章侧重于应用方法，发现生物学规律 Paper1：提出方法 SIGN: similarity identification in gene expression Bioinformatics 2019 / 2 IF...
1、算法简介 1.1 关系拆解 通过计算方法( 例如相关性Pearson correlation, 互信息mutual information等)构建的相互关系网络中，节点两两之间...
（1）Computational Drug Repurposing for Alzheimer’s Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies https://www.frontiersin.org/articles/10.3389/fphar.2021.617537/full Front Pharmacol， 2021/06， IF 5.81 （2）gene...
Discovery of drug mode of action and drug repositioning from transcriptional responses August 2, 2010 | PNAS | IF=11.2 10.1073/pnas.1000138107 1、合并PRL cMap 1309种化合物作用于5种细胞系的6100个干扰转录组的差异基因结果。对于同一种化合...
DrugCombDB: a comprehensive database of drug combinations toward the discovery of combinatorial therapy Nucleic Acids Research | 2020 | IF=17 1、数据收集 （1）HTS(high-throughput screening)高通量筛选技术可用于快速...
A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response Nature Communications | 31 March 2022 DOI: https://doi.org/10.1038/s41467-022-29358-6 这篇文章对来自32个乳腺癌细胞系的35276个细胞进行了单细胞转录组测序(Drop-seq)，...
A single-cell and spatially resolved atlas of human breast cancers NatGenet. 2021 September 1、scRNAseq测序样本 文章对26个乳腺癌样本进行了单细胞测序，包括11 ER+，5 HER2+，10 TNBC。 对...