This report is generated using the results obtained from the UCSCXenaShiny::mol_quick_analysis function. The analysis encompasses 5 sections, each executed for mRNA TP53 sourced from the dataset in UCSC Xena TOIL(TCGA) hub. All TCGA projects are analyzed individually and some cancer projects may be missing due to few samples with valid data for some analysis. The notation for statistical significance analysis is as follows: * indicates a P-value less than 0.05, ** indicates a P-value less than 0.01, and *** indicates a P-value less than 0.001.
Please note that our Shiny app offers more comprehensive exploration possibilities, including alternative datasets for the same molecule, alternative analysis methods, molecule-molecule analysis, personalized sample filtering and grouping, result visualization, and download options.
This part compares the distribution of mRNA TP53 in Normal group samples using across all TCGA projects. For mRNA and transcript data type, samples from GTEx project are also included in Normal groups.
This part compares the distribution of mRNA TP53 between Tumor and Normal group samples using the Wilcoxon test across all TCGA projects. For mRNA and transcript data type, samples from GTEx project are also included in Normal groups.
"Higher Exp." indicates higher value in Tumor groups, whereas "Lower Exp." indicates lower value in Tumor groups. The red vertical line indicates that P equals 0.05.
This part compares the distribution of mRNA TP53 between Old and Young group samples using the Wilcoxon test across all TCGA projects. Samples aged 60 and above are categorized into the Old group, while those below 60 are grouped into the Young group.
"Higher Exp." indicates higher value in Old groups, whereas "Lower Exp." indicates lower value in Old groups. The red vertical line indicates that P equals 0.05.
This part compares the distribution of mRNA TP53 between Male and Female group samples using the Wilcoxon test across all TCGA projects.
"Higher Exp." indicates higher value in Male groups, whereas "Lower Exp." indicates lower value in Male groups. The red vertical line indicates that P equals 0.05.
This part compares the distribution of mRNA TP53 among samples in different AJCC Stage using the ANOVA analysis across all TCGA projects.
The red vertical line indicates that P equals 0.05.
This part includes the log-rank test between higher and lower mRNA TP53 groups based on median value in primary tumor samples with valid Overall Survival (OS) data across all TCGA projects.
"Higher risk" indicates higher risk in the group with elevated molecular expression, whereas "Lower risk" indicates lower risk in the group with elevated molecular expression. The red vertical line indicates that P equals 0.05.
This part includes the log-rank test between higher and lower mRNA TP53 groups based on median value in primary tumor samples with valid Progression-Free Interval (PFI) data across all TCGA projects.
"Higher risk" indicates higher risk in the group with elevated molecular expression, whereas "Lower risk" indicates lower risk in the group with elevated molecular expression. The red vertical line indicates that P equals 0.05.
This part includes the log-rank test between higher and lower mRNA TP53 groups based on median value in primary tumor samples with valid Disease-Free Interval (DFI) data across all TCGA projects.
"Higher risk" indicates higher risk in the group with elevated molecular expression, whereas "Lower risk" indicates lower risk in the group with elevated molecular expression. The red vertical line indicates that P equals 0.05.
This part includes the log-rank test between higher and lower mRNA TP53 groups based on median value in primary tumor samples with valid Disease-Specific Survival (DSS) survival data across all TCGA projects.
"Higher risk" indicates higher risk in the group with elevated molecular expression, whereas "Lower risk" indicates lower risk in the group with elevated molecular expression. The red vertical line indicates that P equals 0.05.
This part includes the spearman correlation of mRNA TP53 with 5 common Tumor Stemness related items in primary tumor samples across all TCGA projects. They are DMPss, DNAss, EREG-METHss, EREG.EXPss, RNAss.
This part includes the spearman correlation of mRNA TP53 with 2 common Tumor Mutation Burden related items in primary tumor samples across all TCGA projects. They are Non_silent_per_Mb, Silent_per_Mb.
This part includes the spearman correlation of mRNA TP53 with 5 common Genome Instability related items in primary tumor samples across all TCGA projects. They are Cancer_DNA_fraction, Genome_doublings, ploidy, purity, Subclonal_genome_fraction.
This part includes the spearman correlation of mRNA TP53 with 22 CIBERSORT based items in primary tumor samples across all TCGA projects. They are B cell memory, B cell naive, B cell plasma, Eosinophil, Macrophage M0, Macrophage M1, Macrophage M2, Mast cell activated, Mast cell resting, Monocyte, Myeloid dendritic cell activated, Myeloid dendritic cell resting, Neutrophil, NK cell activated, NK cell resting, T cell CD4+ memory activated, T cell CD4+ memory resting, T cell CD4+ naive, T cell CD8+, T cell follicular helper, T cell gamma delta, T cell regulatory (Tregs).
This part includes the spearman correlation of mRNA TP53 with 6 TIMER based items in primary tumor samples across all TCGA projects. They are B cell, Macrophage, Myeloid dendritic cell, Neutrophil, T cell CD4+, T cell CD8+.
This part includes the spearman correlation of mRNA TP53 with 39 XCELL based items in primary tumor samples across all TCGA projects. They are B cell, B cell memory, B cell naive, B cell plasma, Cancer associated fibroblast, Class-switched memory B cell, Common lymphoid progenitor, Common myeloid progenitor, Endothelial cell, Eosinophil, Granulocyte-monocyte progenitor, Hematopoietic stem cell, immune score, Macrophage, Macrophage M1, Macrophage M2, Mast cell, microenvironment score, Monocyte, Myeloid dendritic cell, Myeloid dendritic cell activated, Neutrophil, NK cell, Plasmacytoid dendritic cell, stroma score, T cell CD4+ (non-regulatory), T cell CD4+ central memory, T cell CD4+ effector memory, T cell CD4+ memory, T cell CD4+ naive, T cell CD4+ Th1, T cell CD4+ Th2, T cell CD8+, T cell CD8+ central memory, T cell CD8+ effector memory, T cell CD8+ naive, T cell gamma delta, T cell NK, T cell regulatory (Tregs).
This part includes the spearman correlation of mRNA TP53 with 50 HALLMARK originated items in primary tumor samples across all TCGA projects. See all the items here.
This part includes the spearman correlation of mRNA TP53 with 186 KEGG originated items in primary tumor samples across all TCGA projects. See all the items here. Top 50 most significant terms are selected for visualization.